Thursday, September 19, 2013

Vaccinating Cows Could Sharply Cut E. Coli Published: Sep 18, 2013 | Updated: Sep 19, 2013 By Nancy Walsh, Staff Writer, MedPage Today Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, BSN, RN, Nurse Planner

Widespread vaccination of cattle againstEscherichia coli O157 could vastly decrease the human incidence of disease associated with this pathogen, a mathematical simulation suggested.
If the effects of the vaccine simply reflected its efficacy in cattle, a 50% reduction in cases would be expected because the vaccine has been shown to halve the fecal shedding of the pathogen, according toLouise Matthews, PhD, of the University of Glasgow, and colleagues.
However, because the vaccine targets high-density shedding strains of E. coli O157 -- so-called supershedders -- the decrease in human cases could be expected to reach 83% (95% CI 76-93), the researchers reported online in the Proceedings of the National Academy of Sciences.

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